Recurrent bacterial vaginosis following metronidazole treatment is associated with microbiota richness at diagnosis

Gustin AT, Thurman AR, Chandra N, Schifanella L, Alcaide M, Fichorova R, Doncel GF, Gale M Jr, Klatt NR. Recurrent bacterial vaginosis following metronidazole treatment is associated with microbiota richness at diagnosis. Am J Obstet Gynecol. 2022 Feb;226(2):225.e1-225.e15. doi: 10.1016/j.ajog.2021.09.018. Epub 2021 Sep 22. PMID: 34560047; PMCID: PMC8887553.


A Summary of the Sixth International Workshop on Microbiome in HIV Pathogenesis, Prevention, and Treatment

Sherrill-Mix S, Yang M, Aldrovandi GM, Brenchley JM, Bushman FD, Collman RG, Dandekar S, Klatt NR, Lagenaur LA, Landay AL, Paredes R, Tachedjian G, Turpin JA, Serrano-Villar S, Lozupone CA, Ghosh M. A Summary of the Sixth International Workshop on Microbiome in HIV Pathogenesis, Prevention, and Treatment. AIDS Res Hum Retroviruses. 2022 Mar;38(3):173-180. doi: 10.1089/AID.2021.0173. Epub 2022 Jan 25. PMID: 34969255; PMCID: PMC9009592.


Vaccination Against SARS-CoV-2 Is Associated With a Lower Viral Load and Likelihood of Systemic Symptoms

Bramante CT, Proper JL, Boulware DR, Karger AB, Murray T, Rao V, Hagen A, Tignanelli CJ, Puskarich M, Cohen K, Liebovitz DM, Klatt NR, Broedlow C, Hartman KM, Nicklas J, Ibrahim S, Zaman A, Saveraid H, Belani H, Ingraham N, Christensen G, Siegel L, Sherwood NE, Fricton R, Lee S, Odde DJ, Buse JB, Huling JD. Vaccination Against SARS-CoV-2 Is Associated With a Lower Viral Load and Likelihood of Systemic Symptoms. Open Forum Infect Dis. 2022 Feb 20;9(5):ofac066. doi: 10.1093/ofid/ofac066. PMID: 35392460; PMCID: PMC8982774.


Altered Innate Immunity and Damaged Epithelial Integrity in Vaginal Microbial Dysbiosis

Cheu RK, Mohammadi A, Schifanella L, Broedlow C, Driscoll CB, Miller CJ, Reeves RK, Yudin MH, Hensley-McBain T, Kaul R, Klatt NR. Altered Innate Immunity and Damaged Epithelial Integrity in Vaginal Microbial Dysbiosis. Front Reprod Health. 2022 Jul 13;4:876729. doi: 10.3389/frph.2022.876729. PMID: 36303633; PMCID: PMC9580658.


Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19

Bramante CT, Huling JD, Tignanelli CJ, Buse JB, Liebovitz DM, Nicklas JM, Cohen K, Puskarich MA, Belani HK, Proper JL, Siegel LK, Klatt NR, Odde DJ, Luke DG, Anderson B, Karger AB, Ingraham NE, Hartman KM, Rao V, Hagen AA, Patel B, Fenno SL, Avula N, Reddy NV, Erickson SM, Lindberg S, Fricton R, Lee S, Zaman A, Saveraid HG, Tordsen WJ, Pullen MF, Biros M, Sherwood NE, Thompson JL, Boulware DR, Murray TA; COVID-OUT Trial Team. Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19. N Engl J Med. 2022 Aug 18;387(7):599-610. doi: 10.1056/NEJMoa2201662. PMID: 36070710; PMCID: PMC9945922.


Liver Bacterial Dysbiosis With Non-Tuberculosis Mycobacteria Occurs in SIV-Infected Macaques and Persists During Antiretroviral Therapy

Fisher BS, Fancher KA, Gustin AT, Fisher C, Wood MP, Gale M Jr, Burwitz BJ, Smedley J, Klatt NR, Derby N, Sodora DL. Liver Bacterial Dysbiosis With Non-Tuberculosis Mycobacteria Occurs in SIV-Infected Macaques and Persists During Antiretroviral Therapy. Front Immunol. 2022 Jan 10;12:793842. doi: 10.3389/fimmu.2021.793842. PMID: 35082782; PMCID: PMC8784802.


Metformin and Covid-19: Focused Review of Mechanisms and Current Literature Suggesting Benefit

Ibrahim S, Lowe JR, Bramante CT, Shah S, Klatt NR, Sherwood N, Aronne L, Puskarich M, Tamariz L, Palacio A, Bomberg E, Usher M, King S, Benson B, Vojta D, Tignanelli C, Ingraham N. Metformin and Covid-19: Focused Review of Mechanisms and Current Literature Suggesting Benefit. Front Endocrinol (Lausanne). 2021 Jul 22;12:587801. doi: 10.3389/fendo.2021.587801. PMID: 34367059; PMCID: PMC8342037.


Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection

Jones R, Kroll K, Broedlow C, Schifanella L, Smith S, Hueber B, Shah SV, Ram DR, Manickam C, Varner V, Klatt NR, Reeves RK. Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection. Sci Rep. 2021 Jul 15;11(1):14507. doi: 10.1038/s41598-021-93918-x. PMID: 34267278; PMCID: PMC8282626.


Translocated microbiome composition determines immunological outcome in treated HIV infection

Nganou-Makamdop K, Talla A, Sharma AA, Darko S, Ransier A, Laboune F, Chipman JG, Beilman GJ, Hoskuldsson T, Fourati S, Schmidt TE, Arumugam S, Lima NS, Moon D, Callisto S, Schoephoerster J, Tomalka J, Mugyenyi P, Ssali F, Muloma P, Ssengendo P, Leda AR, Cheu RK, Flynn JK, Morou A, Brunet-Ratnasingham E, Rodriguez B, Lederman MM, Kaufmann DE, Klatt NR, Kityo C, Brenchley JM, Schacker TW, Sekaly RP, Douek DC. Translocated microbiome composition determines immunological outcome in treated HIV infection. Cell. 2021 Jul 22;184(15):3899-3914.e16. doi: 10.1016/j.cell.2021.05.023. Epub 2021 Jul 7. PMID: 34237254; PMCID: PMC8316372.


Microbial mismanagement: how inadequate treatments for vaginal dysbiosis drive the HIV epidemic in women

Gustin A., Cromarty R., Schifanella L., Klatt NR. Microbial mismanagement: how inadequate treatments for vaginal dysbiosis drive the HIV epidemic in women. Semin Immunol. 2021 Jun 10:101482. doi: 10.1016/j.smim.2021.101482. Epub ahead of print. PMID: 34120819.


Syndemics and pre-exposure prophylaxis are independently associated with rectal immune dysregulation in sexual minority men

Tapia GR, Glynn TR, Miller C, Manuzak JA, Broedlow CA, Mcgaugh A, Cherenack EM, Bauermeister JA, Grov C, Dilworth SE, Parisi R, Martinez D, Klatt NR, Carrico AW. Syndemics and pre-exposure prophylaxis are independently associated with rectal immune dysregulation in sexual minority men. AIDS. 2021 Mar 10. doi: 10.1097/QAD.0000000000002866. Epub ahead of print. PMID: 33710016.


Effects of persistent modulation of intestinal microbiota on SIV/HIV vaccination in rhesus macaques

Klatt NR, Broedlow C, Osborn JM, Gustin AT, Dross S, O'Connor MA, Coronado E, Barnette P, Hensley-McBain T, Zevin AS, Muir R, Roederer A, Wangari S, Iwayama N, Ahrens CY, Smedley J, Moats C, Lynch RM, Haddad EK, Haigwood NL, Fuller DH, Manuzak JA. Effects of persistent modulation of intestinal microbiota on SIV/HIV vaccination in rhesus macaques. NPJ Vaccines. 2021 Mar 11;6(1):34. doi: 10.1038/s41541-021-00298-4. PMID: 33707443; PMCID: PMC7952719.


SIV susceptibility, immunology and microbiome in the female genital tract of adolescent versus adult pigtail macaques.

Berard AR, Miller C, Araínga M, Broedlow CA, Noël-Romas L, Schifanella L, Hensley-McBain T, Roederer A, Driscoll C, Coronado E, Manuzak J, McKinnon LR, Villinger FJ, Hope TJ, Burgener AD, Klatt NR. SIV susceptibility, immunology and microbiome in the female genital tract of adolescent versus adult pigtail macaques. AIDS Res Hum Retroviruses. 2021 Jan 15. doi: 10.1089/AID.2020.0271. Epub ahead of print. PMID: 33446027.


In Vitro Exposure of Leukocytes to HIV Preexposure Prophylaxis Decreases Mitochondrial Function and Alters Gene Expression Profiles.

Bowman ER, Cameron C, Richardson B, Kulkarni M, Gabriel J, Kettelhut A, Hornsby L, Kwiek JJ, Turner AN, Malvestutto C, Bazan J, Koletar SL, Doblecki-Lewis S, Lederman MM, Cameron M, Klatt NR, Lake JE, Funderburg NT. In Vitro Exposure of Leukocytes to HIV Preexposure Prophylaxis Decreases Mitochondrial Function and Alters Gene Expression Profiles. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01755-20. doi: 10.1128/AAC.01755-20. PMID: 33020165.


Impact of vaginal microbiome communities on HIV antiretroviral-based pre-exposure prophylaxis (PrEP) drug metabolism.

Cheu RK, Gustin AT, Lee C, Schifanella L, Miller CJ, Ha A, Kim C, Rodriguez VJ, Fischl M, Burgener AD, Arnold KB, Alcaide ML, Klatt NR. Impact of vaginal microbiome communities on HIV antiretroviral-based pre-exposure prophylaxis (PrEP) drug metabolism. PLoS Pathog. 2020 Dec 3;16(12):e1009024. doi: 10.1371/journal.ppat.1009024. PMID: 33270801; PMCID: PMC7714160.


Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis.

Lee CY, Cheu RK, Lemke MM, Gustin AT, France MT, Hampel B, Thurman AR, Doncel GF, Ravel J, Klatt NR, Arnold KB. Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis. Nat Commun. 2020 Dec 1;11(1):6147. doi: 10.1038/s41467-020-19880-w. PMID: 33262350; PMCID: PMC7708644.


Timothy Ray Brown: The Serendipitous Hero of HIV Cure Research.

Hope TJ, Klatt NR, Sacha JB, Cannon PM. Timothy Ray Brown: The Serendipitous Hero of HIV Cure Research. AIDS Res Hum Retroviruses. 2020 Nov;36(11):883-885. doi: 10.1089/AID.2020.0253. PMID: 33050710.


Blue Monday: Co-Occurring Stimulant Use and HIV Persistence Predict Dysregulated Catecholamine Synthesis.

Chahine A, Koru-Sengul T, Feaster DJ, Dilworth SE, Antoni MH, Klatt N, Roach ME, Pallikkuth S, Sharkey M, Salinas J, Stevenson M, Pahwa S, Fuchs D, Carrico AW. Blue Monday: Co-Occurring Stimulant Use and HIV Persistence Predict Dysregulated Catecholamine Synthesis. J Acquir Immune Defic Syndr. 2020 Oct 30. doi: 10.1097/QAI.0000000000002560. Epub ahead of print. PMID: 33165125.


A Summary of the Fifth Annual Virology Education HIV Microbiome Workshop.

Sherrill-Mix S, Connors K, Aldrovandi GM, Brenchley JM, Boucher C, Bushman FD, Collman RG, Dandekar S, Klatt NR, Lagenaur LA, Paredes R, Tachedjian G, Turpin JA, Landay AL, Ghosh M. A Summary of the Fifth Annual Virology Education HIV Microbiome Workshop. AIDS Res Hum Retroviruses. 2020 Nov;36(11):886-895. doi: 10.1089/AID.2020.0121. Epub 2020 Sep 7. PMID: 32777940.


Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge.

Om K, Paquin-Proulx D, Montero M, Peachman K, Shen X, Wieczorek L, Beck Z, Weiner JA, Kim D, Li Y, Mdluli T, Shubin Z, Bryant C, Sharma V, Tokarev A, Dawson P, White Y, Appelbe O, Klatt NR, Tovanabutra S, Estes JD, Matyas GR, Ferrari G, Alving CR, Tomaras GD, Ackerman ME, Michael NL, Robb ML, Polonis V, Rolland M, Eller MA, Rao M, Bolton DL. Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge. PLoS Pathog. 2020 Sep 3;16(9):e1008764. doi: 10.1371/journal.ppat.1008764. PMID: 32881968; PMCID: PMC7505435.


Sex Work Is Associated With Increased Vaginal Microbiome Diversity in Young Women From Mombasa, Kenya.

Sivro A, Mwatelah R, Kambaran C, Gebrebrhan H, Becker MG, Ma H, Klatt NR, Zevin AS, King'ola N, Wambua S, Gichangi P, Cheuk E, McLaren PJ, Mishra S, Becker M, McKinnon LR. Sex Work Is Associated With Increased Vaginal Microbiome Diversity in Young Women From Mombasa, Kenya. J Acquir Immune Defic Syndr. 2020 Sep 1;85(1):79-87. doi: 10.1097/QAI.0000000000002406. PMID: 32433252.


Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity.

Martino C, Kellman BP, Sandoval DR, Clausen TM, Marotz CA, Song SJ, Wandro S, Zaramela LS, Salido Benítez RA, Zhu Q, Armingol E, Vázquez-Baeza Y, McDonald D, Sorrentino JT, Taylor B, Belda-Ferre P, Liang C, Zhang Y, Schifanella L, Klatt NR, Havulinna AS, Jousilahti P, Huang S, Haiminen N, Parida L, Kim HC, Swafford AD, Zengler K, Cheng S, Inouye M, Niiranen T, Jain M, Salomaa V, Esko JD, Lewis NE, Knight R. Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity. bioRxiv [Preprint]. 2020 Aug 18:2020.08.17.238444. doi: 10.1101/2020.08.17.238444. PMID: 32839779; PMCID: PMC7444296.


Candida rugosa lipase alters the gastrointestinal environment in wild-type mice.

Menden A, Hall D, Broedlow CA, Darcey T, Crawford F, Klatt N, Crynen S, Mullan M, Ait-Ghezala G. Candida rugosa lipase alters the gastrointestinal environment in wild-type mice. Biomed Pharmacother. 2020 Oct;130:110579. doi: 10.1016/j.biopha.2020.110579. Epub 2020 Aug 6. PMID: 32771891.


Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade.

SahBandar IN, Chew GM, Corley MJ, Pang APS, Tsai N, Hanks N, Khadka VS, Klatt NR, Hensley-McBain T, Somsouk M, Vujkovic-Cvijin I, Chow DC, Shikuma CM, Ndhlovu LC. Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade. AIDS. 2020 Aug 1;34(10):1451-1460. doi: 10.1097/QAD.0000000000002557. PMID: 32675558; PMCID: PMC7371239.


Correction: Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques.

Manuzak JA, Zevin AS, Cheu R, Richardson B, Modesitt J, Hensley-McBain T, Miller C, Gustin AT, Coronado E, Gott T, Fang M, Cartwright M, Wangari S, Agricola B, May D, Smith E, Hampel HB, Gale M, Cameron CM, Cameron MJ, Smedley J, Klatt NR. Correction: Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques. Mucosal Immunol. 2020 May;13(3):558. doi: 10.1038/s41385-020-0274-x. Erratum for: Mucosal Immunol. 2020 May;13(3):471-480. PMID: 32094503.


Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques.

Manuzak JA, Zevin AS, Cheu R, Richardson B, Modesitt J, Hensley-McBain T, Miller C, Gustin AT, Coronado E, Gott T, Fang M, Cartwright M, Wangari S, Agricola B, May D, Smith E, Hampel HB, Gale M, Cameron CM, Cameron MJ, Smedley J, Klatt NR. Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques. Mucosal Immunol. 2020 May;13(3):471-480. doi: 10.1038/s41385-019-0238-1. Epub 2019 Dec 4. Erratum in: Mucosal Immunol. 2020 Feb 24;: PMID: 31797911; PMCID: PMC7183431.


Simian-Human Immunodeficiency Virus SHIV.CH505 Infection of Rhesus Macaques Results in Persistent Viral Replication and Induces Intestinal Immunopathology.

Bar KJ, Coronado E, Hensley-McBain T, O'Connor MA, Osborn JM, Miller C, Gott TM, Wangari S, Iwayama N, Ahrens CY, Smedley J, Moats C, Lynch RM, Haddad EK, Haigwood NL, Fuller DH, Shaw GM, Klatt NR, Manuzak JA.
J Virol. 2019 Aug 28;93(18). pii: e00372-19. doi: 10.1128/JVI.00372-19. Print 2019 Sep 15.


Brief Report: Hazardous Cannabis Use and Monocyte Activation Among Methamphetamine Users With Treated HIV Infection.

Vidot DC, Manuzak JA, Klatt NR, Pallikkuth S, Roach M, Dilworth SE, Pahwa S, Carrico AW.

J Acquir Immune Defic Syndr. 2019 Jul 1;81(3):361-364. doi: 10.1097/QAI.0000000000002046.


Association of Systemic Inflammation With Retinal Vascular Caliber in Patients With AIDS.

Jabs DA, Van Natta ML, Trang G, Jones N, Milush JM, Cheu R, Klatt NR, Pak JW, Danis RP, Hunt PW.
Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2218-2225. doi: 10.1167/iovs.18-26070.


Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection.

Hensley-McBain T, Wu MC, Manuzak JA, Cheu RK, Gustin A, Driscoll CB, Zevin AS, Miller CJ, Coronado E, Smith E, Chang J, Gale M Jr, Somsouk M, Burgener AD, Hunt PW, Hope TJ, Collier AC, Klatt NR.

PLoS Pathog. 2019 Apr 11;15(4):e1007672. doi: 10.1371/journal.ppat.1007672. eCollection 2019 Apr.


The Evolving Facets of Bacterial Vaginosis: Implications for HIV Transmission.

McKinnon LR, Achilles SL, Bradshaw CS, Burgener A, Crucitti T, Fredricks DN, Jaspan HB, Kaul R, Kaushic C, Klatt N, Kwon DS, Marrazzo JM, Masson L, McClelland RS, Ravel J, van de Wijgert JHHM, Vodstrcil LA, Tachedjian G. The Evolving Facets of Bacterial Vaginosis: Implications for HIV Transmission. AIDS Res Hum Retroviruses. 2019 Mar;35(3):219-228. doi: 10.1089/AID.2018.0304. PMID: 30638028; PMCID: PMC6434601.


Association of Age-related Macular Degeneration With Mortality in Patients With Acquired Immunodeficiency Syndrome; Role of Systemic Inflammation.

Jabs DA, Van Natta ML, Trang G, Jones NG, Milush JM, Cheu R, Klatt NR, Danis RP, Hunt PW.
Am J Ophthalmol. 2019 Mar;199:230-237. doi: 10.1016/j.ajo.2018.12.002. Epub 2018 Dec 12.


CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques.

Shah SV, Manickam C, Ram DR, Kroll K, Itell H, Permar SR, Barouch DH, Klatt NR, Reeves RK.

Cell Rep. 2018 Dec 4;25(10):2766-2774.e3. doi: 10.1016/j.celrep.2018.11.020.


Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection.

Guillén Y, Noguera-Julian M, Rivera J, Casadellà M, Zevin AS, Rocafort M, Parera M, Rodríguez C, Arumí M, Carrillo J, Mothe B, Estany C, Coll J, Bravo I, Herrero C, Saz J, Sirera G, Torrella A, Navarro J, Crespo M, Negredo E, Brander C, Blanco J, Calle ML, Klatt NR, Clotet B, Paredes R. Mucosal Immunol. 2019 Jan;12(1):232-246. doi: 10.1038/s41385-018-0083-7. Epub 2018 Aug 31.


Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques.

O'Connor MA, Tisoncik-Go J, Lewis TB, Miller CJ, Bratt D, Moats CR, Edlefsen PT, Smedley J, Klatt NR, Gale M Jr, Fuller DH.

Nat Commun. 2018 Aug 22;9(1):3371. doi: 10.1038/s41467-018-05826-w.


Intestinal damage precedes mucosal immune dysfunction in SIV infection.

Hensley-McBain T, Berard AR, Manuzak JA, Miller CJ, Zevin AS, Polacino P, Gile J, Agricola B, Cameron M, Hu SL, Estes JD, Reeves RK, Smedley J, Keele BF, Burgener AD, Klatt NR. Mucosal Immunol. 2018 Sep;11(5):1429-1440. doi: 10.1038/s41385-018-0032-5. Epub 2018 Jun 15.


Microbial Effects on Immunity in HIV: Virus, Gender or Sexual Preference Induced?

Klatt NR, Manuzak JA.EBioMedicine. 2018 Apr 7. pii: S2352-3964(18)30136-1. doi: 10.1016/j.ebiom.2018.04.008.


Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.

Fisher BS, Green RR, Brown RR, Wood MP, Hensley-McBain T, Fisher C, Chang J, Miller AD, Bosche WJ, Lifson JD, Mavigner M, Miller CJ, Gale M Jr., Silvestri G, Chahroudi A, Klatt NR, Sodora DL.PLoS Pathog. 2018 Feb 21;14(2):e1006871. doi: 10.1371/journal.ppat.1006871.


Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Individuals.

Manuzak JA, Gott TM, Kirkwood JS, Coronado E, Hensley-McBain T, Miller C, Cheu RK, Collier AC, Funderburg NT, Martin JN, Wu MC, Isoherranen N, Hunt PW, Klatt NR.Clin Infect Dis. 2018 Feb 17. doi: 10.1093/cid/cix1116.


The Dual Role of Neutrophils in HIV Infection.

Hensley-McBain T, Klatt NR. Curr HIV/AIDS Rep. 2018 Feb;15(1):1-10. doi: 10.1007/s11904-018-0370-7. Review.


Antibiotic treatment disrupts bacterial communities in the colon and rectum of simian immunodeficiency virus-infected macaques.

Zevin AS, Hensley-McBain T, Miller C, Smith E, Langevin S, Klatt NR. FEMS Microbiol Lett. 2017 Dec 15;364(23). doi: 10.1093/femsle/fnx228.


MicroRNAs: novel tools to block gut inflammation in HIV?

Klatt NR, Hunt PW.AIDS. 2017 Sep 10;31(14):2017-2018. doi: 10.1097/QAD.0000000000001609.


Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women 

Klatt NR, Cheu R, Birse K, Zevin AS, Perner M, Noël-Romas L, Grobler A, Westmacott G, Xie IY, Butler J, Mansoor L, McKinnon LR,

Passmore JS, Abdool Karim Q, Abdool Karim SS, Burgener AD. Science. 2017 Jun 2;356(6341):938-945. doi: 10.1126/science.aai9383.


Analysis of the In Vivo Turnover of CD4+ T-Cell Subsets in Chronically SIV-Infected Sooty Mangabeys.

Ortiz AM, Carnathan DG, Yu J, Sheehan KM, Kim P, Reynaldi A, Vanderford TH, Klatt NR, Brenchley JM, Davenport MP, Silvestri G.

PLoS One. 2016 May 26;11(5):e0156352. doi: 10.1371/journal.pone.0156352. eCollection 2016.


Effects of Fecal Microbial Transplantation on Microbiome and Immunity in Simian Immunodeficiency Virus-Infected Macaques.

Hensley-McBain T, Zevin AS, Manuzak J, Smith E, Gile J, Miller C, Agricola B, Katze M, Reeves RK, Kraft CS, Langevin S, Klatt NR.

J Virol. 2016 Apr 29;90(10):4981-9. doi: 10.1128/JVI.00099-16. Print 2016 May 15.


Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function.

Manuzak JA, Hensley-McBain T, Zevin AS, Miller C, Cubas R, Agricola B, Gile J, Richert-Spuhler L, Patilea G, Estes JD, Langevin S,

Reeves RK, Haddad EK, Klatt NR. J Immunol. 2016 Mar 1;196(5):2401-9. doi: 10.4049/jimmunol.1502470. Epub 2016 Jan 29.


Microbial translocation and microbiome dysbiosis in HIV-associated immune activation.

Zevin AS, McKinnon L, Burgener A, Klatt NR. Curr Opin HIV AIDS. 2016 Mar;11(2):182-90. doi: 10.1097/COH.0000000000000234.


Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques.

Vujkovic-Cvijin I, Swainson LA, Chu SN, Ortiz AM, Santee CA, Petriello A, Dunham RM, Fadrosh DW, Lin DL, Faruqi AA, Huang Y,

Apetrei C, Pandrea I, Hecht FM, Pilcher CD, Klatt NR, Brenchley JM, Lynch SV, McCune JM. Cell Rep. 2015 Nov 24;13(8):1589-97.

doi: 10.1016/j.celrep.2015.10.026. Epub 2015 Nov 12.


Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection.

Hao XP, Lucero CM, Turkbey B, Bernardo ML, Morcock DR, Deleage C, Trubey CM, Smedley J, Klatt NR, Giavedoni LD, Kristoff J, Xu

A, Del Prete GQ, Keele BF, Rao SS, Alvord WG, Choyke PL, Lifson JD, Brenchley JM, Apetrei C, Pandrea I, Estes JD. Nat Commun.

2015 Aug 18;6:8020. doi: 10.1038/ncomms9020.


SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated With Liver Damage.

Evans TI, Li H, Schafer JL, Klatt NR, Hao XP, Traslavina RP, Estes JD, Brenchley JM, Reeves RK. J Infect Dis. 2016 Feb 1;213(3):361-9.

doi: 10.1093/infdis/jiv404. Epub 2015 Aug 3.


HIV and mucosal barrier interactions: consequences for transmission and pathogenesis.

Burgener A, McGowan I, Klatt NR. Curr Opin Immunol. 2015 Oct;36:22-30. doi: 10.1016/j.coi.2015.06.004. Epub 2015 Jul 4. Review.


Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection.

Li H, Richert-Spuhler LE, Evans TI, Gillis J, Connole M, Estes JD, Keele BF, Klatt NR, Reeves RK. PLoS Pathog. 2014 Dec

11;10(12):e1004551. doi: 10.1371/journal.ppat.1004551. eCollection 2014 Dec.


Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals.

Klatt NR, Bosinger SE, Peck M, Richert-Spuhler LE, Heigele A, Gile JP, Patel N, Taaffe J, Julg B, Camerini D, Torti C, Martin JN,

Deeks SG, Sinclair E, Hecht FM, Lederman MM, Paiardini M, Kirchhoff F, Brenchley JM, Hunt PW, Silvestri G. PLoS Pathog. 2014 Aug

28;10(8):e1004345. doi: 10.1371/journal.ppat.1004345. eCollection 2014 Aug.